Kjeld Schmiegelow Selected Research

Mercaptopurine (6 Mercaptopurine)

5/2022	Thiopurine Enhanced ALL Maintenance (TEAM): study protocol for a randomized study to evaluate the improvement in disease-free survival by adding very low dose 6-thioguanine to 6-mercaptopurine/methotrexate-based maintenance therapy in pediatric and adult patients (0-45 years) with newly diagnosed B-cell precursor or T-cell acute lymphoblastic leukemia treated according to the intermediate risk-high group of the ALLTogether1 protocol.
1/2022	Maintenance therapy for acute lymphoblastic leukemia: basic science and clinical translations.
1/2022	DNA-thioguanine concentration and relapse risk in children and young adults with acute lymphoblastic leukemia: an IPD meta-analysis.
11/2021	Maintenance therapy and risk of osteonecrosis in children and young adults with acute lymphoblastic leukemia: a NOPHO ALL2008 sub-study.
4/2021	TPMT polymorphisms and minimal residual disease after 6-mercaptopurine post-remission consolidation therapy of childhood acute lymphoblastic leukaemia.
1/2021	Dynamics of leucocyte DNA thioguanine nucleotide levels during maintenance therapy of childhood acute lymphoblastic leukemia.
1/2021	Effects of NT5C2 Germline Variants on 6-Mecaptopurine Metabolism in Children With Acute Lymphoblastic Leukemia.
1/2021	Acute lymphoblastic leukemia and down syndrome: 6-mercaptopurine and methotrexate metabolites during maintenance therapy.
1/2021	No association between relapse hazard and thiopurine methyltransferase geno- or phenotypes in non-high risk acute lymphoblastic leukemia: a NOPHO ALL2008 sub-study.
1/2020	Pharmacokinetics of tablet and liquid formulations of oral 6-mercaptopurine in children with acute lymphoblastic leukemia.

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Kjeld Schmiegelow Research Topics

Disease

98	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 11/2022 - 01/2002
44	Neoplasms (Cancer) 05/2022 - 11/2003
17	Pancreatitis 01/2022 - 10/2012
12	Leukemia 01/2022 - 01/2002
10	Hypersensitivity (Allergy) 01/2022 - 10/2012
10	Infections 01/2021 - 01/2002
7	Thromboembolism 01/2022 - 01/2016
7	Fever (Fevers) 01/2020 - 01/2002
6	Residual Neoplasm 01/2022 - 05/2013
6	Non-Hodgkin Lymphoma (Lymphosarcoma) 10/2012 - 09/2004
5	Thrombosis (Thrombus) 01/2022 - 01/2020
5	Osteonecrosis (Kienbock's Disease) 11/2021 - 01/2016
5	Thrombocytopenia (Thrombopenia) 10/2020 - 11/2008
5	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2019 - 06/2013
5	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2018 - 04/2006
4	Lymphoma (Lymphomas) 05/2022 - 05/2012
4	Seizures (Absence Seizure) 01/2022 - 01/2016
4	Hepatic Veno-Occlusive Disease (Disease, Hepatic Veno-Occlusive) 01/2022 - 01/2017
4	Vomiting 01/2022 - 08/2018
4	Nausea 01/2022 - 08/2018
4	Brain Neoplasms (Brain Tumor) 01/2021 - 01/2003
4	Down Syndrome (Down's Syndrome) 01/2021 - 10/2006
4	Mucositis 10/2020 - 01/2017
4	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL) 01/2020 - 06/2011
3	Central Nervous System Diseases (CNS Diseases) 01/2022 - 09/2004
3	Stomatitis 11/2021 - 07/2012
3	Pain (Aches) 11/2021 - 07/2012
3	Inflammation (Inflammations) 10/2020 - 01/2015
3	Abdominal Pain (Pain, Abdominal) 10/2020 - 01/2017
3	Adrenal Insufficiency (Adrenal Gland Hypofunction) 01/2017 - 08/2003
3	Neutropenia 01/2015 - 06/2006
2	Anaphylaxis (Anaphylactic Shock) 01/2022 - 03/2015
2	Posterior Leukoencephalopathy Syndrome 01/2022 - 01/2016
2	Hemorrhage 01/2022 - 10/2020
2	Venous Thromboembolism 10/2020 - 05/2020
2	Bacteremia 01/2020 - 01/2017
2	Philadelphia Chromosome 01/2020 - 02/2016
2	Hyperlipidemias (Hyperlipidemia) 01/2020 - 01/2017
2	Hypertension (High Blood Pressure) 01/2020 - 01/2016
2	Genetic Predisposition to Disease (Genetic Predisposition) 01/2019 - 01/2019
2	Disease Progression 01/2019 - 04/2014
2	Birth Weight (Birth Weights) 01/2018 - 10/2003
2	Peripheral Nervous System Diseases (PNS Diseases) 01/2017 - 01/2016
2	Pathologic Complete Response 11/2016 - 04/2013
2	Pneumocystis Pneumonia (Pneumocystis carinii Pneumonia) 01/2016 - 01/2012
2	Leukopenia 01/2015 - 10/2014
2	Liver Diseases (Liver Disease) 10/2014 - 06/2006
2	Pneumonia (Pneumonitis) 01/2012 - 01/2002
2	Chromosome Aberrations (Chromosome Abnormalities) 08/2006 - 06/2003
1	Death (Near-Death Experience) 10/2022

Drug/Important Bio-Agent (IBA)

40	Methotrexate (Mexate)FDA LinkGeneric 05/2022 - 04/2003
33	Mercaptopurine (6 Mercaptopurine)FDA LinkGeneric 05/2022 - 04/2003
29	Asparaginase (Elspar)FDA Link 11/2022 - 08/2002
19	DNA (Deoxyribonucleic Acid)IBA 01/2022 - 06/2002
17	Thioguanine (Tioguanine)FDA Link 05/2022 - 01/2009
11	NucleotidesIBA 01/2022 - 08/2010
10	2-mercaptopurineIBA 05/2022 - 06/2013
9	EnzymesIBA 11/2022 - 01/2012
9	Pharmaceutical PreparationsIBA 01/2022 - 10/2004
8	pegaspargase (Oncaspar)FDA Link 01/2022 - 01/2015
8	thiopurine methyltransferase (thiopurine S-methyltransferase)IBA 01/2021 - 08/2010
7	Biological ProductsIBA 01/2022 - 06/2003
5	antiarrhythmic peptide (AAP)IBA 01/2022 - 04/2014
4	Biomarkers (Surrogate Marker)IBA 01/2022 - 08/2006
4	ORALIT (ORS)IBA 01/2022 - 04/2010
4	Hydrocortisone (Cortisol)FDA LinkGeneric 11/2016 - 08/2003
3	Proteins (Proteins, Gene)FDA Link 01/2022 - 05/2012
3	Dexamethasone (Maxidex)FDA LinkGeneric 07/2020 - 08/2003
3	Anti-Bacterial Agents (Antibiotics)IBA 01/2020 - 01/2002
3	RNA (Ribonucleic Acid)IBA 01/2019 - 01/2009
3	AntibodiesIBA 02/2018 - 08/2002
3	Cytarabine (Cytosar-U)FDA LinkGeneric 01/2018 - 11/2008
3	Prednisolone (Predate)FDA LinkGeneric 11/2016 - 06/2003
2	AntiemeticsIBA 01/2022 - 05/2020
2	insulin receptor-related receptor (IRR)IBA 01/2022 - 11/2021
2	Morphine (MS Contin)FDA LinkGeneric 11/2021 - 07/2012
2	purineIBA 11/2021 - 01/2020
2	LipidsIBA 01/2020 - 01/2020
2	Insulin (Novolin)FDA Link 01/2019 - 01/2017
2	CreatinineIBA 01/2019 - 01/2018
2	Infliximab (Remicade)FDA Link 02/2018 - 01/2018
2	VaccinesIBA 01/2017 - 11/2016
2	Transaminases (Aminotransferases)IBA 01/2015 - 10/2014
2	AntimetabolitesIBA 01/2012 - 06/2011
2	Sulfamethoxazole Drug Combination Trimethoprim (Co-Trimoxazole)FDA LinkGeneric 01/2012 - 01/2002
2	Adrenocorticotropic Hormone (ACTH)FDA Link 08/2011 - 08/2003
2	Etoposide (VP 16)FDA LinkGeneric 10/2006 - 10/2004
2	Mannose-Binding Lectin (Mannan-Binding Lectin)IBA 06/2006 - 11/2002
2	Doxorubicin (Adriamycin)FDA LinkGeneric 04/2006 - 10/2004

Therapy/Procedure

88	Therapeutics 05/2022 - 01/2002
29	Drug Therapy (Chemotherapy) 01/2022 - 06/2002
7	Aftercare (After-Treatment) 01/2021 - 08/2003
6	Radiotherapy 01/2022 - 01/2003
2	Hormonal Contraception 01/2022 - 10/2018
2	Treatment Delay 10/2020 - 02/2016
2	Transplantation 01/2019 - 07/2013
2	Artificial Respiration (Mechanical Ventilation) 01/2019 - 01/2017
2	Stem Cell Transplantation 07/2013 - 04/2011
2	Drug Tapering 11/2008 - 10/2006
2	Maintenance Chemotherapy 04/2003 - 06/2002